Cortan 20mg Tablet

✔️ Uses of Cortan 20mg Tablet

Allergic reactions/conditions

✔️ How does Cortan 20mg Tablet work?

Cortan 20mg Tablet belongs to Glucocorticoids. It works by binding to the receptor and inhibits the release of inflammatory substances thus helping in the treatment of inflammation or allergic disorders.

✔️ Side Effects of Cortan 20mg Tablet

Increased hunger, indigestion, agitation, and restlessness are all common adverse effects. Darkening or lightening of skin color, dizziness or lightheadedness, flushing of the face or cheeks, hiccups, increased sweating, and the impression of spinning is less common or rare adverse effects.

✔️ Quick Suggestions:

• Cortan 20mg Tablet helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system.
• Do not use it more often or for longer than advised by your doctor.
• Take it with food to avoid an upset stomach.
• Cortan 20mg Tablet can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.
• Side effects such as mood changes or stomach problems can happen when you start taking Cortan 20mg Tablet. Inform your doctor if this bothers you.
• Do not stop taking Cortan 20mg Tablet suddenly without talking to your doctor first as it may worsen your symptoms.

✔️ Indication

• Rheumatic Disorders include post-traumatic osteoarthritis, acute gouty arthritis, acute nonspecific tenosynovitis, psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute and subacute bursitis, and acute nonspecific tenosynovitis.
• Endocrine disorders include nonsuppurative thyroiditis, primary or secondary adrenocortical insufficiency, congenital adrenal hyperplasia, and hypercalcemia linked to cancer.
• Pemphigus, bullous dermatitis herpetiformis, severe erythema multiforme, exfoliative dermatitis, mycosis fungoides, and severe psoriasis are examples of dermatological conditions.
• Seasonal or persistent allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, and adverse drug reactions are examples of allergic states.
• Symptomatic sarcoidosis, berylliosis, fulminating, and aspiration pneumonitis are respiratory diseases.
• Hematologic disorders include acquired (autoimmune) hemolytic anemia, erythroblastopenia, secondary thrombocytopenia, and idiopathic thrombocytopenic purpura (RBC anemia).
• Edematous States: To cause diuresis or remission of proteinuria in nephrotic syndrome, without uremia, whether it be of the idiopathic type or that caused by lupus erythematosus.
• Regional enteritis and ulcerative colitis are gastrointestinal disorders.
• Gastrointestinal Diseases: Ulcerative colitis, regional enteritis.

✔️ Pharmacology

Prednisolone is a synthetic adrenocortical drug that functions similarly to glucocorticoids. The Phospholipase A2 enzyme, which produces inflammatory mediators like leukotrienes, SRS-A, and prostaglandins, is inhibited by prednisolone. Prednisolone is quickly and completely absorbed from the GI tract after oral ingestion. Prednisolone has a half-life of 2 to 4 hours before it is excreted and is 70–90% protein-bound in the plasma. The liver is where it is primarily processed, and urine is where it is eliminated.

✔️ Dosage & Administration of Cortan 20mg Tablet

Adult-

Allergic Conditions:

• Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime.
• Day 2: 5 mg PO before breakfast, after lunch, and after dinner, and 10 mg at bedtime.
• Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime.
• Day 4: 5 mg PO before breakfast, after lunch, and at bedtime.
• Day 5: 5 mg PO before breakfast and at bedtime.
• Day 6: 5 mg PO before breakfast.

Nephrotic Syndrome:

• Initial: 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times/day until urine is protein-free for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks.
• Maintenance dose: 0.5 to 1 mg/kg/ dose given every other day for 3 to 6 months.

Anti-inflammatory: 

• 5 to 60 mg per day in divided doses 1 to 4 times/day.

Acute Asthma: 

• 40-60 mg/day PO in a single daily dose or divided q12 hr for 3-10 days.

Pediatric-

Asthma:

• 1 year: Acute: 10 mg orally every 12 hours. Maintenance: 10 mg orally every other day.
• 1 to 4 years: Acute: 20 mg orally every 12 hours. Maintenance: 20 mg orally every other day.
• 5 to 12 years: Acute: 30 mg orally every 12 hours. Maintenance: 30 mg orally every other day.
• 12 years: Acute: 40 mg orally every 12 hours. Maintenance: 40 mg orally every other day.

Anti-inflammatory: 

• 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

Immunosuppression: 

• 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

✔️ Interaction

• Medicines used to treat tuberculosis (e.g. rifampicin, isoniazid): These medications may reduce the effectiveness of Cortan 20mg Tablet.
• Blood thinners (e.g. aspirin, warfarin): There is an increased risk of bleeding when taking these medications concurrently with Cortan 20mg Tablet. Close monitoring of blood clotting parameters may be necessary.
• Antiepilepsy drugs (e.g. carbamazepine, phenobarbital, phenytoin): These medications may reduce the effectiveness of Cortan 20mg Tablet.
• Anticholinergics (e.g. amitriptyline): Concurrent use with Cortan 20mg Tablet may increase the risk of certain side effects such as increased intraocular pressure and urinary retention.
• Medicines used for myasthenia gravis (e.g. neostigmine): Cortan 20mg Tablet may interact with these medications, potentially altering their effects.
• Antidiabetic medications (e.g. insulin): Cortan 20mg Tablet can increase blood sugar levels, which may require adjustments in the dosage of antidiabetic medications.
• HIV medications (e.g. cobicistat): There may be interactions between Cortan 20mg Tablet and certain HIV medications, so close monitoring is advised.
• Sex hormones (e.g. estrogen): Concurrent use with Cortan 20mg Tablet may increase the risk of side effects associated with corticosteroid use.
• NSAIDs (e.g. ibuprofen, naproxen): These medications can increase the risk of gastrointestinal bleeding when taken with Cortan 20mg Tablet.
• Diuretics (e.g. thiazides, furosemide, ethacrylic acid): Concurrent use with Cortan 20mg Tablet may potentiate the effects of diuretics, leading to electrolyte imbalances.
• Medicines used to treat lung diseases or asthma (e.g. theophylline, salbutamol, terbutaline, salmeterol, formoterol): These medications may interact with Cortan 20mg TabletG, and careful monitoring of respiratory function may be required.
• Antibiotic used for fungal infection (e.g. amphotericin B): Cortan 20mg Tablet may increase the risk of side effects associated with amphotericin B.
• Regarding food interactions, Cortan 20mg Tablet should not be taken with grapefruit or rich protein foods as they may affect the absorption or metabolism of the medication.

It's important to note that this is not an exhaustive list of all possible drug interactions. Always consult with your healthcare provider or pharmacist for a comprehensive understanding of potential interactions before starting Cortan 20mg Tablet or any other medication.

✔️ Contraindications

Cortan 20mg Tablet should not be used in the following situations:

Systemic infections: Cortan 20mg Tablet should not be used in the presence of systemic infections unless specific anti-infective therapy is also employed. Corticosteroids can suppress the immune system, making it difficult for the body to fight off infections.

Hypersensitivity: If you have a known hypersensitivity or allergy to any of the ingredients in Cortan 20mg Tablet, it should be avoided.

Ocular herpes simplex: Cortan 20mg Tablet should not be used in individuals with ocular herpes simplex due to the potential risk of corneal perforation. Corticosteroids can exacerbate viral infections such as herpes simplex.

✔️ Pregnancy & Lactation

Cortan 20mg Tablet is not recommended for use during pregnancy unless it is considered essential by a doctor. The decision to use this medication during pregnancy should only be made if the expected benefit to the mother outweighs any potential risk to the fetus. Corticosteroids, including Cortan 20mg Tablet, can cross into breast milk and may have the potential to suppress growth, interfere with the production of natural corticosteroids in infants, or cause other unwanted effects.

If you are pregnant or breastfeeding, it is crucial to discuss the potential risks and benefits of using Cortan 20mg Tablet with your healthcare provider. They will be able to evaluate your individual situation and provide guidance on the most appropriate treatment options for you and your baby.

✔️ Precautions & Warnings

• Some anti-inflammatory compounds in ginger can help relax airway membranes, reducing coughing.
• Staying hydrated by drinking liquids at room temperature can alleviate symptoms such as cough, runny nose, and sneezing.
• Acid reflux is a common cause of cough. Avoiding foods that can trigger acid reflux can help alleviate the accompanying cough.
• Stress can affect the immune system and increase the risk of illness. Regular exercise, meditation, deep breathing, and relaxation techniques can help relieve stress and support a healthy immune system.
• Getting 7-9 hours of sleep each night is important for overall fitness and well-being.
• Avoiding allergens: If you have known allergies, it is advised to avoid contact with allergens such as pollen, dust, or specific food items that cause allergic reactions.
• Maintaining personal hygiene and keeping the surroundings clean can help prevent the spread of infections.
• It is important not to suggest your medicine to someone else and to consult with a doctor before taking any medication, including Cortan 20mg Tablet. Inform your doctor about your medical history, ongoing medications, and any allergies or conditions you may have.
• Cortan 20mg Tablet should be used with caution in individuals with specific medical conditions such as hypothyroidism, liver disease, kidney failure, seizures, myasthenia gravis, tuberculosis, gastrointestinal disorders, heart disorders, blood disorders, mood swings, psychotic tendencies, adrenal gland disorders, and scleroderma. It can cause side effects such as dizziness, visual problems, and fatigue. Care should be taken while driving or operating machinery.
• Regular height check-ups by a doctor are recommended for children and teenagers using to detect any growth-related issues early.
• High or immunosuppressive dosages of corticosteroids may affect the administration of life or live-attenuated vaccinations. Consult with a healthcare professional regarding the use of inactivated viral or bacterial vaccinations.

✔️ Storage Conditions

Store in a cool and dry place, protected from light. Keep out of the reach of the children.